Metformin-Clinical Pharmacology in PCOs

Unlicensed use of metformin in children and adolescents in the UK.

AIM Metformin is the most commonly prescribed oral anti-diabetic drug in young people. It is also prescribed for polycystic ovarian syndrome (PCOS) and obesity treatment in adults in an unlicensed fashion. Little is known as to the extent metformin has been used in young people. We investigated the use of metformin in children and adolescents aged 0-18 years in the UK. METHODS Population-base...

I-17: Should All Women with PCOS-Related Infertility Be Treated with Insulin Sensitizing Drugs?

Interest in the role of insulin sensitizing drugs (ISDs) as a means of reducing compensatory hyperinsulinemia in the hope of improving metabolic and reproductive functions in women with PCOS has grown measurably over the past decade. Metformin is believed to lower fasting serum insulin levels in insulin-resistance. For the management of ovulatory infertility in the nonobese PCOS population (BMI...

Co-Administration of Metformin and N-Acetyl Cysteine Fails to Improve Clinical Manifestations in PCOS Individual Undergoing ICSI

I-40: Relationship Between Abnormal GlucoseTolerance Test and History of Previous Recurrent Miscarriages, and Beneficial Effecof Metformin in These Patients: A Prospective Clinical Study

Background: To determine the incidence of an abnormal glucose tolerance test in patients with recurrent spontaneous abortion and whether metformin would safely reduce the rate of first trimester spontaneous abortions in patients without polycystic ovary syndrome (PCOS) as well as with PCOS and an abnormal glucose tolerance test. Materials and Methods: Patients with a history of recurrent sponta...

Efficacy and safety of metformin or oral contraceptives, or both in polycystic ovary syndrome

BACKGROUND Polycystic ovary syndrome (PCOS) is an endocrinopathy that affects approximately 10% of reproductive-aged women throughout their lives. Women with PCOS present with heterogeneous symptoms including ovulatory dysfunction, hyperandrogenism, and polycystic ovaries. Therefore, lifelong individualized management should be considered. Pharmacological agents commonly used to manage the symp...